In vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.

TitleIn vivo selection of Plasmodium falciparum Pfcrt and Pfmdr1 variants by artemether-lumefantrine and dihydroartemisinin-piperaquine in Burkina Faso.
Publication TypeJournal Article
Year of Publication2015
AuthorsBaraka, V, Tinto, H, Valea, I, Fitzhenry, R, Delgado-Ratto, C, Mbonye, MK, Van Overmeir, C, Rosanas-Urgell, A, Van Geertruyden, J-P, D'Alessandro, U, Erhart, A
JournalAntimicrob Agents Chemother
Volume59
Issue1
Pagination734-7
Date Published2015 Jan
ISSN1098-6596
KeywordsAntimanic Agents, Artemisinins, Burkina Faso, Drug Combinations, Drug Resistance, Ethanolamines, Fluorenes, Genetic Variation, Humans, Malaria, Falciparum, Membrane Transport Proteins, Multidrug Resistance-Associated Proteins, Plasmodium falciparum, Protozoan Proteins, Quinolines
Abstract

Plasmodium falciparum Pfcrt-76 and Pfmdr1-86 gene polymorphisms were determined during a clinical trial in Burkina Faso comparing the efficacies of dihydroartemisinin-piperaquine (DHA-PPQ) and artemether-lumefantrine (AL). Significant selection of Pfcrt-K76 was observed after exposure to AL and DHA-PPQ, as well as selection of Pfmdr1-N86 after AL but not DHA-PPQ treatment, suggesting reverse selection on the Pfcrt gene by PPQ. These results support the rational use of DHA-PPQ in settings where chloroquine (CQ) resistance is high.

DOI10.1128/AAC.03647-14
Alternate JournalAntimicrob. Agents Chemother.
PubMed ID25403659
PubMed Central IDPMC4291431