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| Title | High mortality associated with retreatment of tuberculosis in a clinic in Kampala, Uganda: a retrospective study. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Acuña-Villaorduña, C, Ayakaka, I, Dryden-Peterson, S, Nakubulwa, S, Worodria, W, Reilly, N, Hosford, J, Fennelly, KP, Okwera, A, Jones-López, EC |
| Journal | Am J Trop Med Hyg |
| Volume | 93 |
| Issue | 1 |
| Pagination | 73-5 |
| Date Published | 2015 Jul |
| ISSN | 1476-1645 |
| Keywords | Adult, Antitubercular Agents, Coinfection, Ethambutol, Female, Follow-Up Studies, HIV Infections, Humans, Isoniazid, Male, Middle Aged, Proportional Hazards Models, Pyrazinamide, Recurrence, Retreatment, Retrospective Studies, Rifampin, Streptomycin, Survival Rate, Treatment Failure, Treatment Outcome, Tuberculosis, Uganda |
| Abstract | The World Health Organization recommends for tuberculosis retreatment a regimen of isoniazid (H), rifampicin (R), ethambutol (E), pyrazinamide (Z), and streptomycin (S) for 2 months, followed by H, R, E, and Z for 1 month and H, R, and E for 5 months. Using data from the National Tuberculosis and Leprosy Program registry, this study determined the long-term outcome under programmatic conditions of patients who were prescribed the retreatment regimen in Kampala, Uganda, between 1997 and 2003. Patients were traced to determine their vital status; 62% (234/377) patients were found dead. Having ≤ 2 treatment courses and not completing retreatment were associated with mortality in adjusted analyses. |
| DOI | 10.4269/ajtmh.14-0810 |
| Alternate Journal | Am. J. Trop. Med. Hyg. |
| PubMed ID | 25940196 |
| PubMed Central ID | PMC4497908 |
| Grant List | K23 AI091434 / AI / NIAID NIH HHS / United States |