High mortality associated with retreatment of tuberculosis in a clinic in Kampala, Uganda: a retrospective study.

TitleHigh mortality associated with retreatment of tuberculosis in a clinic in Kampala, Uganda: a retrospective study.
Publication TypeJournal Article
Year of Publication2015
AuthorsAcuña-Villaorduña, C, Ayakaka, I, Dryden-Peterson, S, Nakubulwa, S, Worodria, W, Reilly, N, Hosford, J, Fennelly, KP, Okwera, A, Jones-López, EC
JournalAm J Trop Med Hyg
Volume93
Issue1
Pagination73-5
Date Published2015 Jul
ISSN1476-1645
KeywordsAdult, Antitubercular Agents, Coinfection, Ethambutol, Female, Follow-Up Studies, HIV Infections, Humans, Isoniazid, Male, Middle Aged, Proportional Hazards Models, Pyrazinamide, Recurrence, Retreatment, Retrospective Studies, Rifampin, Streptomycin, Survival Rate, Treatment Failure, Treatment Outcome, Tuberculosis, Uganda
Abstract

The World Health Organization recommends for tuberculosis retreatment a regimen of isoniazid (H), rifampicin (R), ethambutol (E), pyrazinamide (Z), and streptomycin (S) for 2 months, followed by H, R, E, and Z for 1 month and H, R, and E for 5 months. Using data from the National Tuberculosis and Leprosy Program registry, this study determined the long-term outcome under programmatic conditions of patients who were prescribed the retreatment regimen in Kampala, Uganda, between 1997 and 2003. Patients were traced to determine their vital status; 62% (234/377) patients were found dead. Having ≤ 2 treatment courses and not completing retreatment were associated with mortality in adjusted analyses.

DOI10.4269/ajtmh.14-0810
Alternate JournalAm. J. Trop. Med. Hyg.
PubMed ID25940196
PubMed Central IDPMC4497908
Grant ListK23 AI091434 / AI / NIAID NIH HHS / United States