In vitro infection of human primary adipose cells with HIV-1: a reassessment.

TitleIn vitro infection of human primary adipose cells with HIV-1: a reassessment.
Publication TypeJournal Article
Year of Publication2003
AuthorsMunier, S, Borjabad, A, Lemaire, M, Mariot, V, Hazan, U
JournalAIDS (London, England)
Volume17
Issue17
Pagination2537-9
Date Published2003 Nov 21
ISSN0269-9370
KeywordsAdipocytes, Adipose Tissue, Antigens, CD4, Gene Expression, Hela Cells, HIV Infections, HIV-1, Humans, Receptors, CCR5, Receptors, CXCR4, Transfection
Abstract

We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G-pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.

Alternate JournalAIDS
Full Text
PubMed ID14600528