Virological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection.

TitleVirological evaluation of the 'Ottawa case' indicates no evidence for HIV-1 superinfection.
Publication TypeJournal Article
Year of Publication2004
AuthorsAngel, JB, Hu, Y-W, Kravcik, S, Tsui, R, Lee, KH, Barbour, J, Balaskas, E, Branson, BM, Delwart, EL, Grant, RM
JournalAIDS (London, England)
Volume18
Issue2
Pagination331-4
Date Published2004 Jan 23
ISSN0269-9370
KeywordsAntiretroviral Therapy, Highly Active, Disease Progression, Drug Resistance, Viral, HIV Infections, HIV-1, Homosexuality, Male, Humans, Male, Mutation, Sequence Analysis, Sexual Partners, Superinfection, Viral Load
Abstract

An HIV-1 infected man who experienced rapid disease progression and poor response to therapy after starting a new sexual relationship with an infected partner is known as the 'Ottawa superinfection case'. Subsequent analysis of viral sequences of protease, reverse transcriptase, Gag p17, and Env V3 provided no evidence for the acquisition of genetically divergent viruses before disease progression or drug resistance during virological failure of combination therapy. Whether HIV-1 superinfection contributes to disease progression or the spread of drug-resistant HIV-1 remains unknown.

Alternate JournalAIDS
Full Text
PubMed ID15075555