Salivary production of IgA and IgG to human herpes virus 8 latent and lytic antigens by patients in whom Kaposi's sarcoma has regressed.

TitleSalivary production of IgA and IgG to human herpes virus 8 latent and lytic antigens by patients in whom Kaposi's sarcoma has regressed.
Publication TypeJournal Article
Year of Publication2004
AuthorsMbopi-Keou, F-X, Legoff, J, Piketty, C, Hocini, H, Malkin, J-E, Inoue, N, Scully, CM, Porter, SR, Teo, C-G, Belec, L
JournalAIDS (London, England)
Volume18
Issue2
Pagination338-40
Date Published2004 Jan 23
ISSN0269-9370
KeywordsAntibodies, Viral, Antibody Specificity, Antigens, Viral, Enzyme-Linked Immunosorbent Assay, Herpesvirus 8, Human, Humans, Immunoglobulin A, Secretory, Immunoglobulin G, Saliva, Sarcoma, Kaposi
Abstract

IgG and IgA antibodies with specificities to a latent and a lytic antigen of human herpes virus 8 (HHV-8) were detectable in the saliva and serum of eight patients whose Kaposi's sarcoma had regressed, seven of whom were HIV-1 infected. The measurement of antibody-specific activity and secretion rate, and the detection of secretory IgA all indicate anti-HHV-8 antibody activity in saliva. The specific humoral responses possibly influence mucosal replication of HHV-8, and in turn, that of HIV.

Alternate JournalAIDS
Full Text
PubMed ID15075558