Microbial translocation, the innate cytokine response, and HIV-1 disease progression in Africa.

TitleMicrobial translocation, the innate cytokine response, and HIV-1 disease progression in Africa.
Publication TypeJournal Article
Year of Publication2009
AuthorsRedd, AD, Dabitao, D, Bream, JH, Charvat, B, Laeyendecker, O, Kiwanuka, N, Lutalo, T, Kigozi, G, Tobian, AAR, Gamiel, J, Neal, JD, Oliver, AE, Margolick, JB, Sewankambo, N, Reynolds, SJ, Wawer, MJ, Serwadda, D, Gray, RH, Quinn, TC
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue16
Pagination6718-23
Date Published2009 Apr 21
ISSN1091-6490
KeywordsAdult, Africa, Antigens, CD14, Bacteria, Biological Markers, Biological Transport, Cytokines, Disease Progression, Female, HIV Infections, HIV-1, Humans, Immunity, Innate, Inflammation Mediators, Lipopolysaccharides, Male, Solubility, United States
Abstract

Reports from the United States have demonstrated that elevated markers of microbial translocation from the gut may be found in chronic and advanced HIV-1 infection and are associated with an increase in immune activation. However, this phenomenon's role in HIV-1 disease in Africa is unknown. This study examined the longitudinal relationship between microbial translocation and circulating inflammatory cytokine responses in a cohort of people with varying rates of HIV-1 disease progression in Rakai, Uganda. Multiple markers for microbial translocation (lipopolysaccharide, endotoxin antibody, and sCD14) did not change significantly during HIV-1 disease progression. Moreover, circulating immunoreactive cytokine levels either decreased or remained virtually unchanged throughout disease progression. These data suggest that microbial translocation and its subsequent inflammatory immune response do not have a causal relationship with HIV-1 disease progression in Africa.

Alternate JournalProc. Natl. Acad. Sci. U.S.A.
Full Text
PubMed ID19357303
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