|Title||Interpretation of undetectable hepatitis C virus RNA levels in HIV-hepatitis C virus co-infection.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Cooper, CL, Cameron, WD|
|Journal||AIDS (London, England)|
|Date Published||2004 Jan 23|
|Keywords||Adult, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Female, Hepacivirus, Hepatitis C, Chronic, HIV Infections, Humans, Male, RNA, Viral|
Individuals with positive hepatitis C virus (HCV) antibody titres, normal transaminase levels, and undetectable HCV-RNA levels are generally considered to have cleared the previous hepatitis C infection. We report the emergence of plasma HCV RNA within a cohort of HIV and HCV seropositive/plasma HCV-RNA-negative patients initiating highly active antiretroviral therapy. Our observations challenge conventional wisdom that HCV polymerase chain reaction-negative patients with normal liver enzymes are 'cured'.