Interpretation of undetectable hepatitis C virus RNA levels in HIV-hepatitis C virus co-infection.

TitleInterpretation of undetectable hepatitis C virus RNA levels in HIV-hepatitis C virus co-infection.
Publication TypeJournal Article
Year of Publication2004
AuthorsCooper, CL, Cameron, WD
JournalAIDS (London, England)
Volume18
Issue2
Pagination337-8
Date Published2004 Jan 23
ISSN0269-9370
KeywordsAdult, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Female, Hepacivirus, Hepatitis C, Chronic, HIV Infections, Humans, Male, RNA, Viral
Abstract

Individuals with positive hepatitis C virus (HCV) antibody titres, normal transaminase levels, and undetectable HCV-RNA levels are generally considered to have cleared the previous hepatitis C infection. We report the emergence of plasma HCV RNA within a cohort of HIV and HCV seropositive/plasma HCV-RNA-negative patients initiating highly active antiretroviral therapy. Our observations challenge conventional wisdom that HCV polymerase chain reaction-negative patients with normal liver enzymes are 'cured'.

Alternate JournalAIDS
Full Text
PubMed ID15075557