ShareThis| Title | Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients. |
| Publication Type | Journal Article |
| Year of Publication | 2002 |
| Authors | Doherty, MT, Demissie A, Olobo J, Wolday D, Britton S, Eguale T, Ravn P, Andersen P |
| Journal | Journal of clinical microbiology |
| Volume | 40 |
| Issue | 2 |
| Pagination | 704-6 |
| Date Published | 2002 Feb |
| ISSN | 0095-1137 |
| Keywords | Antigens, Bacterial, Bacterial Proteins, Contact Tracing, Disease Progression, Family Characteristics, Humans, Interferon-gamma, Leukocytes, Mononuclear, Mycobacterium tuberculosis, Tuberculosis, Pulmonary |
| Abstract | Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period. |
| Alternate Journal | J. Clin. Microbiol. |
| Attachment | Size |
|---|---|
| doherty-olobo-chs-res.pdf | 58.04 KB |
