Immune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients.

TitleImmune responses to the Mycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts of tuberculosis patients.
Publication TypeJournal Article
Year of Publication2002
AuthorsDoherty, MT, Demissie, A, Olobo, J, Wolday, D, Britton, S, Eguale, T, Ravn, P, Andersen, P
JournalJournal of clinical microbiology
Volume40
Issue2
Pagination704-6
Date Published2002 Feb
ISSN0095-1137
KeywordsAntigens, Bacterial, Bacterial Proteins, Contact Tracing, Disease Progression, Family Characteristics, Humans, Interferon-gamma, Leukocytes, Mononuclear, Mycobacterium tuberculosis, Tuberculosis, Pulmonary
Abstract

Diagnosis of latent Mycobacterium tuberculosis infection is considered essential for tuberculosis control but is hampered by the lack of specific reagents. We report that strong recognition of tuberculosis complex-specific antigen ESAT-6 by healthy household contacts of tuberculosis patients correlates with the subsequent development of active tuberculosis during a 2-year follow-up period.

Alternate JournalJ. Clin. Microbiol.
Full Text
PubMed ID11826002
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