|Title||Hepatitis C infection increases the risk of the modification of first highly active antiretroviral therapy in HIV-infected patients.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Ripamonti, D, Arici, C, Pezzotti, P, Maggiolo, F, Ravasio, L, Suter, F|
|Journal||AIDS (London, England)|
|Date Published||2004 Jan 23|
|Keywords||Adult, Aged, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Female, Hepatitis C, HIV Infections, Humans, Male, Middle Aged, Patient Acceptance of Health Care, Risk Factors|
We assessed predictors of discontinuation or change of the first regimen of highly active antiretroviral therapy in 465 HIV-infected adults, in the first year. A total of 187 patients modified their regimen: 45 discontinuing and 142 changing because of clinical/virological failure, intolerance/toxicity or non-adherence. Predictors of modification of the regimen were hepatitis C seropositivity, liver cirrhosis, higher baseline viral load, sex (women had a lower risk) and calendar year (lower risk staring in 2000).