Hepatitis C infection increases the risk of the modification of first highly active antiretroviral therapy in HIV-infected patients.

TitleHepatitis C infection increases the risk of the modification of first highly active antiretroviral therapy in HIV-infected patients.
Publication TypeJournal Article
Year of Publication2004
AuthorsRipamonti, D, Arici, C, Pezzotti, P, Maggiolo, F, Ravasio, L, Suter, F
JournalAIDS (London, England)
Volume18
Issue2
Pagination334-7
Date Published2004 Jan 23
ISSN0269-9370
KeywordsAdult, Aged, AIDS-Related Opportunistic Infections, Antiretroviral Therapy, Highly Active, Female, Hepatitis C, HIV Infections, Humans, Male, Middle Aged, Patient Acceptance of Health Care, Risk Factors
Abstract

We assessed predictors of discontinuation or change of the first regimen of highly active antiretroviral therapy in 465 HIV-infected adults, in the first year. A total of 187 patients modified their regimen: 45 discontinuing and 142 changing because of clinical/virological failure, intolerance/toxicity or non-adherence. Predictors of modification of the regimen were hepatitis C seropositivity, liver cirrhosis, higher baseline viral load, sex (women had a lower risk) and calendar year (lower risk staring in 2000).

Alternate JournalAIDS
Full Text
PubMed ID15075556