|Title||On the general theory of the origins of retroviruses.|
|Publication Type||Journal Article|
|Year of Publication||2010|
|Journal||Theoretical biology & medical modelling|
|Keywords||Animals, DNA, Viral, Evolution, Molecular, Humans, Models, Biological, Replication Origin, Retroviridae, Simian foamy virus|
The order retroviridae comprises viruses based on ribonucleic acids (RNA). Some, such as HIV and HTLV, are human pathogens. Newly emerged human retroviruses have zoonotic origins. As far as has been established, both repeated infections (themselves possibly responsible for the evolution of viral mutations (Vm) and host adaptability (Ha)); along with interplay between inhibitors and promoters of cell tropism, are needed to effect retroviral cross-species transmissions. However, the exact modus operandi of intertwine between these factors at molecular level remains to be established. Knowledge of such intertwine could lead to a better understanding of retrovirology and possibly other infectious processes. This study was conducted to derive the mathematical equation of a general theory of the origins of retroviruses.
|Alternate Journal||Theor Biol Med Model|