On the general theory of the origins of retroviruses.

TitleOn the general theory of the origins of retroviruses.
Publication TypeJournal Article
Year of Publication2010
AuthorsWayengera, M
JournalTheoretical biology & medical modelling
Volume7
Pagination5
Date Published2010
ISSN1742-4682
KeywordsAnimals, DNA, Viral, Evolution, Molecular, Humans, Models, Biological, Replication Origin, Retroviridae, Simian foamy virus
Abstract

The order retroviridae comprises viruses based on ribonucleic acids (RNA). Some, such as HIV and HTLV, are human pathogens. Newly emerged human retroviruses have zoonotic origins. As far as has been established, both repeated infections (themselves possibly responsible for the evolution of viral mutations (Vm) and host adaptability (Ha)); along with interplay between inhibitors and promoters of cell tropism, are needed to effect retroviral cross-species transmissions. However, the exact modus operandi of intertwine between these factors at molecular level remains to be established. Knowledge of such intertwine could lead to a better understanding of retrovirology and possibly other infectious processes. This study was conducted to derive the mathematical equation of a general theory of the origins of retroviruses.

Alternate JournalTheor Biol Med Model
Full Text
PubMed ID20158888