Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia.

TitleCommunity-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia.
Publication TypeJournal Article
Year of Publication2001
AuthorsYoshimine, H, Oishi, K, Mubiru, F, Nalwoga, H, Takahashi, H, Amano, H, Ombasi, P, Watanabe, K, Joloba, M, Aisu, T, Ahmed, K, Shimada, M, Mugerwa, R, Nagatake, T
JournalThe American journal of tropical medicine and hygiene
Volume64
Issue3-4
Pagination172-7
Date Published2001 Mar-Apr
ISSN0002-9637
KeywordsAdministration, Oral, Adult, Amoxicillin, Ampicillin, Community-Acquired Infections, Drug Administration Schedule, Drug Resistance, Microbial, Female, Haemophilus influenzae, HIV Infections, HIV-1, Humans, Infusions, Intravenous, Male, Microbial Sensitivity Tests, Penicillins, Pneumonia, Bacterial, Prevalence, Prospective Studies, Streptococcus pneumoniae, Treatment Outcome, Uganda
Abstract

A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short-term parenteral ampicillin followed by oral amoxicillin for these patients in relation to HIV-status. We demonstrated a very high prevalence (75%) of HIV-1 infection. No significant difference was observed with respect to age, gender, prior antibiotic usage, symptoms, laboratory data or bacterial etiology between HIV-1-infected and HIV-uninfected CAP patients. Most strains of Streptococcus pneumoniae (n = 19) and Haemophilus influenzae (n = 8) isolated from HIV-1-infected patients were penicillin-resistant (95%) and beta-lactamase producing (75%) strains, respectively. A high percentage of good clinical response was found in both HIV-1-infected (81%) and HIV-uninfected (86%) among 39 patients with CAP due to a defined bacterial pathogen. These data support the use of short-term parenteral ampicillin for patients with bacterial CAP irrespective of HIV-status.

Alternate JournalAm. J. Trop. Med. Hyg.
Full Text
PubMed ID11442214
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