Are girls more at risk of intrauterine-acquired HIV infection than boys?

TitleAre girls more at risk of intrauterine-acquired HIV infection than boys?
Publication TypeJournal Article
Year of Publication2004
AuthorsThorne, C, Newell, M-L
Corporate AuthorsEuropean Collaborative Study,
JournalAIDS (London, England)
Volume18
Issue2
Pagination344-7
Date Published2004 Jan 23
ISSN0269-9370
KeywordsAntiretroviral Therapy, Highly Active, Cohort Studies, Female, HIV Infections, Humans, Infant, Newborn, Infectious Disease Transmission, Vertical, Male, Pregnancy, Pregnancy Complications, Infectious, Risk Factors, Sex Factors
Abstract

To investigate whether previously described sex differences in virological and immunological markers in vertically infected children are preceded by sex differences in the overall risk or timing of mother-to-child transmission (MTCT) we analysed 3231 mother-child pairs enrolled in the European Collaborative Study. Girls were at a 1.5 times increased risk of MTCT overall, but the sex effect was limited to elective caesarean section deliveries, suggesting that girls may have an increased risk of intrauterine transmission compared with boys.

Alternate JournalAIDS
Full Text
PubMed ID15075561