Adoke Yeka

Dr. Adoke Yeka is currently an Assistant Lecturer in the Department of Disease Control and Environmental Health, School of Public Health, College of Health Sciences, Makerere University-Kampala. He trained as a Medical Doctor (MBChB) from Makerere University, Uganda in 1994. He later did his Master of Public Health (MPH) at Makerere University School of Public Health in 2001. He is currently pursuing his PhD, at the university of Antwerp, Belgium. His research focus is on Malaria drug resistance and control.

Since 2002, he has been actively involved in building and implementing a multi-site surveillance system in Uganda to evaluate malaria specific morbidity and mortality, efficacy of available anti-malarial drugs, and potential anti- malarial drug related Adverse Events. He was instrumental in the set up of a National anti-Malaria Drug Efficacy Surveillance Network at 6 sentinel sites and a pilot system for antimalarial drug pharmacovigilance in Uganda. He has conducted antimalarial efficacy, safety and tolerability clinical trials involving over 5,000 patients, in Uganda. These studies have been influential in the rapidly changing approach to antimalarial therapy within Uganda and around Africa.

In collaboration with other scientists, he is evaluating the safety and immunogenicity of a candidate lyophilized recombinant precipitated tropical malaria vaccine (BK-SE36), in Uganda. He has coordinated surveys to estimate malaria specific morbidity, mortality and coverage of key control interventions in Uganda. He has coordinated trainings to build capacity for fever case management in Uganda including training on diagnosis of malaria using microscopy and RDTÔÇÖs, management of severe and uncomplicated malaria and the management of non malaria fevers.

Publications.

 

  1. Van Malderen C, Van Geertruyden JP, Machevo S, González R, Bassat Q, Talisuna A, Yeka A, Nabasumba C, Piola P, Daniel A, Turyakira E, Forret P, Van Overmeir C, van Loen H, Robert A, D 8217 Alessandro U. Glucose-6-phosphate dehydrogenase deficiency, chlorproguanil-dapsone with artesunate and post-treatment haemolysis in African children treated for uncomplicated malaria. Malar J. 2012 Apr 30;11(1):139.
  1. Namagembe A, Ssekabira U, Weaver MR, Blum N, Burnett S, Dorsey G, Sebuyira LM, Ojaku A, Schneider G, Willis K, Yeka A. Improved clinical and laboratory skills after team-based, malaria case management training of health care professionals in Uganda. Malar J. 2012 Feb 13;11:44.

 

  1. Four Artemisinin-Based Combinations (4ABC) Study Group. A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial. PLoS Med. 2011 Nov;8(11):e1001119. Epub 2011 Nov 8.
  1. Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN, Rosenthal PJ, D'Alessandro U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24;10(1):144.

 

  1. Kiggundu M, Nsobya SL, Kamya MR, Filler S, Nasr S, Dorsey G, Yeka A. Evaluation of a comprehensive refresher training program in malaria microscopy covering four districts of Uganda. Am J Trop Med Hyg. 2011 May;84(5):820-4.
  1. Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A, Dorsey G, Kamya MR, Rosenthal PJ. Malaria in Uganda: Challenges to control on the long road to elimination I. Epidemiology and current control efforts. Acta Trop. 2011 Mar 21.

 

  1. Yeka A, Harris JC. Treating uncomplicated malaria in children: comparing artemisinin-based combination therapies. Curr Opin Pediatr. 2010 Dec;22(6):798-803.
  1. Ssekabira U, Bukirwa H, Hopkins H, Namagembe A, Weaver MR, Sebuyira LM, Quick L, Staedke S, Yeka A, Kiggundu M, Schneider G, McAdam K, Wabwire-Mangen F, Dorsey G. Improved malaria case management after integrated team-based training of health care workers in Uganda. Am J Trop Med Hyg. 2008 Dec;79(6):826-33.

 

  1. Zwang J, Olliaro P, Barennes H, Bonnet M, Brasseur P, Bukirwa H, Cohuet S, D'Alessandro U, Djimde A, Martensson A, Yeka A, Karema C, Guthmann JP, Hamour S, Ndiaye JL, Rwagacondo C, Sagara I, Same-Ekobo A, Sirima S, van den Broek I, Taylor WR, Dorsey G, Randrianarivelojosia M: Efficacy of artesunate-amodiaquine for treating uncomplicated P. falciparum malaria in Sub-Saharan Africa: a multi-centre analysis. : Malar J. 2009 Aug 23;8(1):203.
  1. Adoke Yeka, Jane Achan , Umberto DeAllesandro, Ambrose Talisuna. ÔÇ£Quinine monotherapy for treatment of recurrent uncomplicated malaria in the era of ACTÔÇÖs: an appropriate public health policy? The Lancet Infectious Diseases, Volume 9, Issue 7, Pages 448 - 452, July 2009.

 

  1. Adoke Yeka, Grant Dorsey, Moses R. Kamya, Ambrose Talisuna, Myers Lugemwa, John Bosco Rwakimari, Sarah G. Staedke, Philip J. Rosenthal, Fred Wabwire-Mangen, Hasifa Bukirwa. ÔÇ£Artemether-Lumefantrine Versus Dihydroartemisinin-Piperaquine for Treatment of Uncomplicated Falciparum Malaria: A Randomized Trial to Guide National Policy in UgandaÔÇØ PLoS ONE, 2008, Volume 3, Issue 6, e2390
  1. Sarah G. Staedke, Prasanna Jagannathan, Adoke Yeka, Hasifa Bukirwa, Kristin Banek, Catherine Maiteki-Sebuguzi, Tamara D. Clark, Bridget Nzarubara, Denise Njama-Meya, Heidi Hopkins, Philip J. Rosenthal, Moses R. Kamya, Fred Wabwire-Mangen, Grant Dorsey, Ambrose O. Talisuna ÔÇ£Monitoring antimalarial safety and tolerability in clinical trials: a case study from UgandaÔÇØ Malaria Journal 2008, 7:107

 

  1. Moses R. Kamya, Adoke Yeka, Hasifa Bukirwa, Myers Lugemwa, John B. Rwakimari, Sarah G. Staedke, Ambrose O. Talisuna, Bryan Greenhouse, Francois Nosten, Philip J. Rosenthal, Fred Wabwire-Mangen, Grant Dorsey: Artemether-Lumefantrine versus Dihydroartemisinin-Piperaquine for Treatment of Malaria: A Randomized Trial, PLoS Clinical Tials May 2007 e20
  1. Hasifa B, Adoke Y, Moses RK, Ambrose T, Kristin B, Nathan B, John BR, Philip JR, Fred WM, Grant D, Sarah GS. ÔÇ£Artemisinin combination therapies for treatment of uncomplicated malaria in UgandaÔÇØ PLOS Clinical Trials. 2006 May e7.

 

  1. Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A, Rosenthal PJ, Wabwire-Mangen F, Dorsey G. ÔÇ£Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda.ÔÇØ  PLoS Med. 2005 Jul;2(7):e190.
  1. Bakyaita N, Dorsey G, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A, Rosenthal PJ, Wabwire-Mangen F.  ÔÇ£Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda.ÔÇØ  Am J Trop Med Hyg. 2005 May;72(5):573-80.

 

  1. Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D, Rosenthal PJ, Dorsey G, Havlir D.  ÔÇ£Effect of HIV infection on malaria treatment outcomes in Uganda; A population based study.ÔÇØ JID 2006:193:9-15
  1. Lee SA, Yeka A, Nsobya SL, Dokomajilar C, Rosenthal PJ, Talisuna A, Dorsey G.  ÔÇ£Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at seven sites in Uganda.ÔÇØ J Infect Dis. 2006 Apr 15;193(8):1160-3

 

  1. Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C, Rosenthal PJ, Dorsey G.  ÔÇ£Geographic differences in antimalarial drug efficacy explained by differences in endemicity and not molecular markers of drug resistance.ÔÇØ J Infect Dis. 2006 Apr 1;193(7):978-86.
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